Endocrine Abstracts

Weight regain after weight loss is a well described-phenomena in both humans and animal models of obesity and thought to be related to reduced energy expenditure and increased food intake. Reduced lipolysis in white adipose tissue has been described in obesity. We hypothesized that lipolytic defect in adipose tissue in the obese state persists after weight loss increasing efficiency of lipid storing and promotes weight regain. We utilized a mouse model of obesity memory (OM): ...

Corticotropin releasing hormone (CRH) and its related peptides, urocortins (UCN), are now emerging as critical regulators of energy balance and homeostasis. These peptides exert their effects through activation of two types of CRH receptors (CRH-R1 and CRH-R2). The role of these peptides as regulators of mammalian thermogenesis and their effects on brown adipose tissue (BAT) have been primarily attributed to modulation of brain centres controlling sympathetic outflow. However,...